Abstract: Glaucoma is one of the most discussed diseases in ophthalmology. It is defined as a neurodegenerative disease with characteristic changes in the optic disc and the retinal nerve fiber layer. Elevated intraocular pressure (ocular hypertension) is one of the main risk factors for the development of glaucoma.
The aim of this study is to provide an overview and evaluate the effect of prostaglandin analogues (PGAs) on central corneal thickness in patients with glaucoma. Results from randomized and controlled clinical trials are used. Key indicators monitored include central corneal thickness (CCT) at the beginning and end of the study period, intraocular pressure, and
the appearance of other changes in the cornea. Multiple studies are included in the analysis. The aggregated results show that PGAs reduce CCT. The drugs used include Travoprost, Latanoprost, and Bimatoprost. The results indicate that Bimatoprost and Travoprost have a significant effect on CCT. Studies also show that this effect is time-dependent.
Keywords: Prostaglandins, prostaglandin analogues, glaucoma, central corneal thickness.

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