Abstract

Introduction: Colorectal carcinoma (CRC) occurs as a result of accumulation of different types of genome damage. The purpose of the present research was to study and compare APC expression in tumor tissue of synchronous/metachronous adenomas and CRC in connection with clinical and morphological indicators. 

Materials and methods: Materials from 18 synchronous/metachronous colorectal adenomas and 21 CRCs were observed. We used an APC mouse monoclonal antibody for immunohistochemical analysis.

Results: There was no statistically significant difference between the percentage of protein expression in synchronous/metachronous adenomas and clinico-morphological indicators expect their differentiated. There was no statistically significant difference between APC expression percentage in CRC and clinico-pathological parameters. Based on logistic regression analysis, we found a statistically significant difference between protein expression area and lymph node metastases.

Conclusion: APC accumulation in CRC can be used as a prognostic sign for the risk of lymph node metastases.

Keywords: APC, CRC, synchronous/metachronous adenomas, prognostic sign, metastases

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