ABSTRACT 
Diabetes is a serious problem worldwide and affects Bulgaria as well. Late complications of diabetes 
mellitus represent a serious problem for patients. Diabetes mellitus is the most common cause of the 
development of chronic kidney disease (CKD). Early identification and management of CKD is of 
utmost importance to minimize the risk of severe cardiovascular events and premature loss of life. In 
the present retrospective analysis, we followed 86 patients with type 2 diabetes mellitus (T2DM) and 
chronic kidney disease (CKD) from January 2020. until January 2022 In the present retrospective 
analysis, patients were divided into two groups of 43 participants. The first group received their 
standard therapy, while the second group, in addition to standard treatment, was given a sodium 
glucose transporter-2 (SGLT2) inhibitor. Data from this analysis show that in the group of patients 
receiving sodium glucose transporter-2 (SGLT2) inhibitors, between January 2020 and January 
2022, a mean reduction in UACR of 0.37 ± 0.73 was found (P < 0.001) and stabilization of eGFR. In 
the context of the standard therapy group, the results showed that albuminuria remained high and 
the risk of complications continued to be increased. 
Key words: diabetes mellitus type 2, chronic kidney disease, albuminuria 

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